Region 10 Catholic Youth Ministry (Region 10), one of the 14 Regions of the National Federation for Catholic Youth Ministry (NFCYM), is comprised of 18 dioceses in the states of Arkansas, Oklahoma, and Texas. The (arch)dioceses of Region 10 are: Amarillo, Austin, Beaumont, Brownsville, Corpus Christi, Dallas, El Paso, Fort Worth, Galveston-Houston, Little Rock, Laredo, Lubbock, Oklahoma City, San Angelo, San Antonio, Tulsa, Tyler and Victoria.

Region acts as a resource for Diocesan Offices of Youth Ministry and/or Offices designated to serve youth and adults who work with youth where no formal Office of Youth Ministry exists, as well as for other organizations within the Region providing ministry and resources for youth.

Region 10 promotes comprehensive youth ministry as stated in the document, Renewing the Vision: A Framework for Catholic Youth Ministry (1997) and carries out the work of the NFCYM at the Regional and Diocesan level.

Region 10 Catholic Youth Ministry operates as non-profit organization as defined by its association with the United States Conference of Catholic Bishop (USCCB), the NFCYM, and in virtue of being listed in the Catholic Directory as an ecclesiastical region in the United States.